Phenanthridine synthesis via [2+2+2] cyclotrimerization reactions.
نویسندگان
چکیده
A concise synthesis of phenanthridines via a microwave-assisted [2+2+2] cyclotrimerization reaction has been developed.
منابع مشابه
CuCl(2)-induced regiospecifical synthesis of benzene derivatives in the palladium-catalyzed cyclotrimerization of alkynes.
Many metals or their complexes can catalyze the cyclotrimerization of alkynes to give benzene derivatives.1-9 Among these catalysts, palladium chloride10 and its bis(benzonitrile) complex11 are the most convenient. In these reactions, the yields of benzene derivatives generally depend on the substituents of alkynes. In the past 50 years, the regioand chemoselectivity for the cyclotrimerization ...
متن کاملCobalt-mediated cyclotrimerization and cyclo- isomerization reactions. Synthetic applications*
This article reviews our contribution in the ®eld of the cobalt(I)-mediated cyclizations. The use of new unsaturated partners such as allenes extend the scope and the utility of the previously developed intramolecular [222] cyclotrimerization. The presence of chiral auxiliaries induced high level of diastereoselectivity in the enediynes cyclization. The discovery of cobalt(I) catalyzed ene-ty...
متن کاملModular synthesis of phenanthridine derivatives by oxidative cyclization of 2-isocyanobiphenyls with organoboron reagents.
Where HAS you been? A manganese-mediated annulation of 2-isocyanobiaryls with organoboronic acids is developed for the synthesis of a broad range of phenanthridine derivatives. Mechanistic studies indicate that the reaction proceeds by the intramolecular homolytic aromatic substitution (HAS) of an imidoyl radical intermediate.
متن کاملMetal-free cyclotrimerization for the de novo synthesis of pyridines.
The de novo synthesis of pyridines from smaller molecules has attracted a lot of interest since pyridine is one of the most important heterocyclic structural motifs in numerous areas of organic chemistry. Many developed syntheses, such as the Kr hnke or the Hantzsch reaction, rely on condensation reactions of smaller molecules, but a number of synthetic approaches including cycloaddition reacti...
متن کاملA new synthetic approach to 6-unsubstituted phenanthridine and phenanthridine-like compounds under mild and metal-free conditions.
A new and mild synthetic approach for the synthesis of 6-unsubstituted phenanthridine and phenanthridine-like compounds under metal-free conditions at room temperature has been developed. The strategy involved a tandem azide rearrangement/intramolecular annulation and oxidation reactions of biarylmethyl azide precursors to obtain the desired products in up to 99% yields with high regioselectivity.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 6 2 شماره
صفحات -
تاریخ انتشار 2008